Each functional element of the EVOSS device is intended to replicate crucial functions of the human body to provide the most natural respiratory process for organs while in transit. The system is comprised of a consumable module and a durable, reusable base. The single-use consumable is replaced between patients requiring limited effort and coordination. The reusable base is designed for the rigors of organ transport in a variety of vehicles, including ambulances, constrained air ambulances, jets, taxis, and rideshare vehicles.